SUCCESS DURING ADMINISTRATION

The optimal surfactant experience should start with efficient administration that is easy on your staff and may improve tolerability for your babies.

Explore 3 ways that you and your patients may benefit from administration of CUROSURF® (poractant alfa) Intratracheal Suspension:

CUROSURF® (poractant alfa) delivers more surfactant with less volume

As the chart below illustrates, with higher surfactant concentration and phospholipid concentration in each dose of CUROSURF, less volume is needed in the baby’s lungs.1-5 Less volume may improve tolerability and has the potential to reduce complications such as airway obstruction.5

More surfactant, less volume*1-5

Initial and repeat doses of CUROSURF® (poractant alfa) are delivered at a lower volume vs other exogenous surfactants.1-5

CUROSURF delivers more than twice the phospholipid concentration (mg/mL) of other exogenous surfactants.1-5

Dose/Volume Comparison of Exogenous surfactants

*Based on a 1000-g infant and manufacturer’s dosing schedule.

  • Clinical studies have not established that lower volume results in superior efficacy or safety based on clinically relevant end points
  • While clinical studies have demonstrated that phospholipids are an essential element, they have not established the quantity required for optimal surfactant efficacy

Initial and repeat doses of CUROSURF® (poractant alfa) are delivered at a lower volume vs other exogenous surfactants.1-5

CUROSURF delivers more than twice the phospholipid concentration (mg/mL) of other exogenous surfactants.1-5

CUROSURF® spreads fast and evenly

CUROSURF is a thin suspension, which has been shown to spread quickly and evenly.7

CUROSURF distribution in lamb lungs over 4 minutes†1

CUROSURF is a thin intratracheal suspension. Chart shows distribution in lamb lungs over 4 minutes.

Unpublished photos presented during the 15th International Workshop on Surfactant Replacement, 2000.
Preclinical data may not be predictive of clinical results.

CUROSURF® (poractant alfa) administration experience

In an open-label, observational study, CUROSURF demonstrated relatively quick administration and rapid recovery within 1 minute.8 In addition, CUROSURF demonstrated a low reflux rate, which may improve tolerability and ease of administration.8 It has been suggested that the thin suspension may help to minimize airway and endotracheal tube obstruction and associated complications such as transient hypercapnia.6,8

Infants’ administration experience8

CUROSURF is a thin suspension that demonstrates a low reflux rate and fast recovery time after administration.1,8

1st DOSE VOLUME1 % INITIAL DOSES ADMINISTERED IN
UNDER FIVE MIN
REFLUX RATE 5—15 MIN AFTER ADMINISTRATION RECOVERY TIME AFTER ADMINISTRATION
2.5 mL/kg 58.9% 3.5% 81% of babies
recovered within 1 minute

Adapted from Gerdes JS, et al. J Pediatr Pharmacol Ther. 2006.

CUROSURF is a thin suspension that demonstrates a low reflux rate and fast recovery time after administration.1,8